von Willebrand analysis (Citrated plasma, frozen (cp))

Specimens:	1 ml Citrated plasma, frozen (cp)
includes following tests:	von Willebrand factor antigen (vWF:Ag) cp (Citrated plasma, frozen (cp)) vWF: Ac (von Willebrand Factor activity) (Citrated plasma, frozen (cp)) vWF: Ac / vWF: Ag ratio (Citrated plasma, frozen (cp))
Preanalytics/Notes:	Please always send a separate specimen for this test. Two separate tubes citrated plasma (cp), frozen, 1 ml each. Collect citrated blood, centrifuge directly after sampling and transfer citrated blood into a new tube, label this tube accordingly, freeze and dispatch deep-frozen. Please note that this profile is tested in-house in Ingelheim. vWF:Ac/vWF:Ag ratio will always be reported, as well as von Willebrand activity and antigen values.
Method:	Turbidimetry
Set-up:	Mon Tue Wed Thu Fri Sat Sun
Indication/Significance:	Diagnostic assessment of unclear bleeding tendency: tendency to nosebleed (epistaxis) and mucosal bleeding, e.g. bleeding after dental extraction or menorrhagias, are typical. Reference in the family anamnesis is important. Common global tests such as Quick value, PTT or thrombin time are frequently normal. Diagnostic assessment of haemophilia and thrombocytopathy Therapy monitoring
Interpretation:	The von Willebrand's more… The von Willebrand's syndrome (vWS) is the most common cause of a congenital bleeding tendency (mild form up to 2 % of the population). The von Willebrand's syndrome can also be drug-induced (frequently valproate-induced) or acquired, e.g. by autoantibodies and with lymphoproliferative diseases. The syndrome is usually not detected by means of common global tests such as Quick value, PTT or thrombin time. Often, however, the bleeding time is prolonged. vWS can be classified into different types which require different therapeutic consequences. With positive basic diagnostics, special methods are available for differentiation (multimeric analysis, molecular genetic methods). Classification of the hereditary vW syndrome: Type 1: Partial quantitative deficiency of vWF Frequency approx. 70 - 80 %, autosomal dominant inheritance Type 2: Qualitative defect/deficiency in vWF Frequency approx. 15 - 20 %, autosomal dominant or recessive inheritance Type 2 differentiates between 4 different subtypes which can usually be differentiated by means of the multimeric analysis. The most important subtype of these is type 2A. Type 3: Virtually complete quantitative deficiency of vWF: Total absence of vWF (at most traces of vWF:Ag detectable), thus half-life period of factor VIII reduced to 1 hour. The haemophilia-like bleeding type predominates in the end even though the platelet function is also strongly impaired. Types 1 to 3 can be differentiated by the above-mentioned ratio formation: A vWF:Ac/vWf:Ag ratio below 0.6 indicates a type 2. With purely quantitative reductions, i.e. type 1 and type 3, the concentrations of vWF:Ag, factor VIII and vWF:RCo are equally reduced, so the ratio is usually normal. close
Further tests:	Multimeric analysis, molecular genetic analyses

von Willebrand analysis (Citrated plasma, frozen (cp))

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Abrechnung GOÄ