HOMA-Index (Serum, frozen (s))

Specimens:	1 ml NaF-Plasma + 1 ml Serum, frozen (s)
includes following tests:	Glucose (NaF) (NaF plasma (NaF)) Insulin (s) (Serum, frozen (s))
Preanalytics/Notes:	Blood is taken after 12 hours of fasting (very important!). The indicated reference ranges only apply for this 12-hour fasting period. Both analytes required.
Set-up:	on demand
Duration:	4 days
Indication/Significance:	Adiposity (BMI > 28) Suspected insulin resistance (metabolic syndrome, type 2 diabetes) Suspected polycystic ovaries (PCO syndrome) Menstrual disorders (e.g. diagnosis of amenorrhoea) Infertility
Interpretation:	Increased: Indication of more… Increased: Indication of insulin resistance (see reference range). Insulin resistance is a significant pathomechanism in the development of type 2 diabetes and can often be observed even years before it manifests itself within the scope of a metabolic syndrome. Furthermore, a restricted insulin sensitivity can often be found in patients with fertility disorders in PCO syndrome. In pathogenesis, insulin resistance is a major cause of PCO syndrome. Insulin resistance is thus frequently the cause of infertility and menstrual disorders. close
Further tests:	Diagnosis of diabetes: Oral glucose tolerance test, HbA1c, GAD antibodies, insulin antibodies, islet-cell antibodies Diagnosis of amenorrhoea: LH, FSH, oestradiol, prolactin, DHEA-S, TSH

both sex
	< 3,0
> 3.1 Indication of insulin resistance. The specified cut-off applies to a food abstinence of at least 8 hours and insulin measurement using ECLIA (Roche).