Specimens: | 1 ml Citrated plasma, frozen (cp) |
Preanalytics/Notes: | Please always send a separate specimen for this test.
Please note that this profile is a send-out test performed mainly for gel electrophoresis to assess von Willebrand multimer patterns. Von Willebrand activity and antigen values will be reported as well. vWF:Ac/vWF:Ag ratio will be noted only if pathologic. |
Method: | SDS gel electrophoresis |
Set-up: | on demand |
Duration: | 14 days |
Indication/Significance: |
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Interpretation: |
The von Willebrand's more… The von Willebrand's syndrome (vWS) is the most common cause of a congenital bleeding tendency (mild form up to 2 % of the population). The von Willebrand's syndrome can also be drug-induced (frequently valproate-induced) or acquired, e.g. by autoantibodies and with lymphoproliferative diseases. The syndrome is usually not detected by means of common global tests such as Quick value, PTT or thrombin time. Often, however, the bleeding time is prolonged.vWS can be classified into different types which require different therapeutic consequences. With positive basic diagnostics, special methods are available for differentiation (multimeric analysis, molecular genetic methods). Classification of the hereditary vW syndrome:
Types 1 to 3 can be differentiated by the above-mentioned ratio formation:
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Further tests: | Molecular genetic analyses |
sample referred to a partner lab
Die Kosten werden für den i. d. R. genutzten 1,15-fachen GOÄ-Satz dargestellt. Wird die Untersuchung nicht in Ihrem regionalen Labor durchgeführt, erfolgt die Analyse in dem Labor, das im Leistungsverzeichnis genannt ist. In diesem Fall gilt der dort für die Untersuchung angegebene Preis.