Specimens: | 150 µl EDTA blood (eb) |
Method: | Liquid chromatography-tandem mass spectr |
Dimension: | µg/l |
Set-up: | Mon Tue Wed Thu Fri Sat Sun |
Duration: | 2 days |
Indication/Significance: | Therapeutic drug monitoring, adverse effects of drugs, unsatisfactory therapeutic effect |
both sex | ||
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Therapeutic ranges for tacrolimus (trough concentration, LC-MS/MS) post transplantation: Renal transplantation: with corticosteroids and mycophenolate initial therapy: 4 - 12 µg/l maintenance therapy: 4 - 9 µg/l with corticosteroids and everolimus initial therapy: 4 - 7 µg/l maintenance therapy: 2 - 4 µg/l Liver transplantation: with corticosteroids and mycophenolate/or everolimus initial therapy: 6 - 10 µg/l maintenance therapy: 5 - 8 µg/l monotherapy initial therapy: 10 - 15 µg/l maintenance therapy: 5 - 10 µg/l Heart transplantation: with corticosteroids and mycophenolate initial therapy: 10 - 15 µg/l maintenance therapy: 5 - 12 µg/l with corticosteroids and mTOR inhibitor initial therapy: no information maintenance therapy: 3 - 8 µg/l Stem cells: with methotrexate 10 - 20 µg/l References: IATDMCT consensus document 2019: doi: 10.1097/FTD.0000000000000640;ISHLT Guideline 2023: doi: 10.1016/j.healun.2022.10.015 |
Die Kosten werden für den i. d. R. genutzten 1,15-fachen GOÄ-Satz dargestellt. Wird die Untersuchung nicht in Ihrem regionalen Labor durchgeführt, erfolgt die Analyse in dem Labor, das im Leistungsverzeichnis genannt ist. In diesem Fall gilt der dort für die Untersuchung angegebene Preis.