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Serotonin (urine/HPLC) (Urine (u))

Specimens: 10 ml Urine (u)
Preanalytics/Notes: Collect 24 h urine; state the amount collected and the collection period (if deviating from 24 h); if it is a spontaneous urine sample, this must be noted down. Add approx. 4 - 5 drops of 20 % hydrochloric acid to the urine shipment sample (approx. 10 ml of the thoroughly mixed urine collection). Freeze urine sample and dispatch frozen. Patients must stop taking the following medication approx. 3 days beforehand, if medically reasonable: Guafenesin, mephenesine, methocarbamol, paracetamol, salicylic acid. The following foodstuffs are to be avoided approx. 3 days before collection: Pineapples, eggplants, avocados, bananas, currants, kiwis, melons, mirabelles, nuts, plums, gooseberries, tomatoes.
Method: HPLC
Dimension: µg/24h
Set-up: on demand
Duration: 8 days
Indication/Significance:

Suspected carcinoid syndrome with symptoms such as:

Flush reactions, abdominal colics, diarrhoea, paroxysmal dyspnoeic attacks, chronic intermittent incomplete ileus conditions, peptic ulcers.

Note:

As serotonin is rapidly converted into HIAA in the kidney, normal serotonin concentrations in the urine can be found in the case of elevated serotonin levels in EDTA blood. For this reason, the determination of serotonin in EDTA blood is always preferred.
Interpretation:
Further tests:

Confirmation of further GEP-NET tumours:
Insulinoma, glucagonoma, gastrinoma and other, usually very rare neuroendocrine tumours.

sample referred to a partner lab

Reference range / valuation (openclose)

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