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Renin (ep) (EDTA plasma, frozen (ep))

Testcode:	RENING
Specimens:	750 µl EDTA plasma, frozen (ep)
Preanalytics/Notes:	Centrifuge blood within 30 min. after sampling, freeze plasma, dispatch deep-frozen. Caution! Do not cool sample before freezing, but quickly process at room temperature. Renin cannot be requested from material kept at 2-8°C. Cryoactivation may lead to a production of active renin from prorenin (10 times higher plasma concentration than renin) and thus result in false high renin values. In the case of a suspected hyperaldosteronism, the aldosterone-renin ratio (ARR) should initially be determined in the blood. In preparation of blood sampling, patients must stop taking spironolactone, eplerenone, contraceptives containing drospirenone, triamterene and amiloride 4 weeks before the test as they have a lasting effect on the ARR. Liquorice and chewing tobacco should not be consumed in this period. The "permitted" antihypertensive agents include in particular peripheral alpha blockers (e.g. doxazosin) and non-dihydroperidine calcium antagonists (e.g. verapamil). In addition, the potassium levels should be normalised before each test and the patient should be requested to eat a balanced diet, in order to intake the right amount of salt. Information for sampling: Sampling should take place in the morning between 7 and 10 o' clock, about two hours after getting up, in sitting position after 10 to 15 minutes of rest. To avoid a haemolysis, centrifuge blood immediately after sampling, remove plasma with a pipette and freeze (approx. -20°C). Alternatively, the reference ranges are given for adults for blood sampling in recumbent position.
Method:	CLIA
Dimension:	ng/l
Alternate dimension:	pmol/l (Factor: 0.0237) Calculator
Set-up:	Mon Tue Wed Thu Fri Sat Sun
Duration:	1 day
Indication/Significance:	Diagnostic assessment of a resistant hypertonia Three medications make is impossible to monitor hypertonia Hypertensive patients under the age of 40 Diagnosis and differentiation of hyperaldosteronism in combination with renin and functional tests
Interpretation:	Increased: Renovascular more… Increased: Renovascular hypertonia, chronic renal insufficiency, renin-producing tumours, Bartter's syndrome For the differentiation between primary and secondary hyperaldosteronism, it is important to simultaneously determine renin and aldosterone. With primary hyperaldosteronism (Conn's syndrome), aldosterone is increased and renin is decreased. With secondary hyperaldosteronism (e.g. renovascular, renal parenchymatous liver cirrhosis), both parameters are increased. close
Further tests:	Aldosterone in the serum, metanephrine in the plasma

Reference range / valuation (openclose)

both sex
from 0 - 5 Years	6,3 - 149,0 ng/l
from 6 Years - 11 Years	5,5 - 110,0 ng/l
from 12 Years - 16 Years	3,3 - 61,0 ng/l
from 17 Years - 120 Years	2,6 - 28,0 ng/l
1.7 - 24 ng/l [0.04 - 0.57 pmol/l] (afer 30 min recumbent, blood drawing 7 - 10 am) 2.6 - 28 ng/l [0.06 - 0.66 pmol/l] (afer 30 min in upright position, blood drawing 7 - 10 am)

Representation of age: "from" refers to the commenced year(s) (month) of age; "until" refers to the completed year(s) (month) of age.

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Abrechnung GOÄ

Die Kosten werden für den i. d. R. genutzten 1,15-fachen GOÄ-Satz dargestellt. Wird die Untersuchung nicht in Ihrem regionalen Labor durchgeführt, erfolgt die Analyse in dem Labor, das im Leistungsverzeichnis genannt ist. In diesem Fall gilt der dort für die Untersuchung angegebene Preis.