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Quantiferon-TB Gold PlusTest (Other)

Specimens: 4 x 1ml special tube Other
Preanalytics/Notes:

Four special tubes incl. instructions on the preanalytical phase can be obtained from the laboratory. 

Method: Lymphocyte stimulation test
Set-up: Mon Tue Wed Thu Fri Sat Sun
Indication/Significance:
  • Testing those who had contact with an index case with regard to risk contact

Exclusion of a LTBI (latent tuberculosis infection) as a risk in immunosuppression:

  • Prior to immunomodulatory therapy, e.g. TNF alpha blockers (infliximab)
  • In rheumatic therapy and with Crohn's disease, ulcerative colitis or for HIV patients up to approx. 100 CD4 cells/µl
  • Prior to organ transplants and with malignant diseases

Occupational issues:

  • Status ascertainment when being employed in pulmological institutions, laboratory staff as alternative to TST (tuberculin skin test)
  • Suspected active TB as supporting statement in close comparison with medical history and clinical parameters, yet not as replacement for radiological and microbiological verification procedures

Analysis is indicated:

  • Prior to the commencement of an immunosuppressive treatment
  • Prior to organ transplants (kidney, heart, lungs, liver, pancreas)
  • Prior to dialysis treatment
  • Prior to a decision on the treatment of an infection with mycobacterium tuberculosis complex in the case of a HIV infection
Further tests:

Proof of acid-fast rods, e.g. in the sputum/bronchial secretion, TBC cultures, DNA PCR assay from testing material of the affected person

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