Specimens: | 500 µl Serum (s) |
Preanalytics/Notes: | Use gel barrier-free serum tubes (to avoid false low results by adsorption of the analytes) and blood sampling immediately before the next dose (steady-state concentration). |
Method: | Liquid chromatography-tandem mass spectr |
Dimension: | mg/l |
Set-up: | Mon Tue Wed Thu Fri Sat Sun |
Duration: | 2 days |
Interpretation: |
Therapeutic drug more… Therapeutic drug monitoring, adverse effects of drugs, unsatisfactory therapeutic effect |
both sex | ||
---|---|---|
0,5 - 5,0 mg/l | ||
See below. The recommended therapeutic ranges for mycophenolic acid vary depending on the indication for therapy. The following ranges apply for pre-dose blood sampling (LC-MS): Therapy with mycophenolate mofetil (MMF): Kidney transplantation 1.3 - 4.5 mg/l -co-medication with cyclosporine A: 1.3 - 3.5 mg/l -co-medication with tacrolimus: 1.9 - 4.0 mg/l Heart transplantation: > 2.0 mg/l Liver/ bone marrow/ stem cells- transplantation: 1.0 - 3.5 mg/l Lupus nephritis (preliminary): > 3.0 mg/l Therapy with mycophenolate sodium (MPS): Due to the specific pharmacokinetics of MPS, pre- dose concentrations do not necessarily correspond to trough concentrations. Therefore, pre-dose blood samples are not well suited for monitoring MPS therapy and the measured concentrations are just useable for a rough check of the adherence to therapy. Reference: IATDMCT Consensus Document 2021; doi: 10.1097/FTD.0000000000000871 |
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