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Metanephrines (LC-MS/MS) (ep) (EDTA plasma, frozen (ep))

Specimens: 1 ml EDTA plasma, frozen (ep)
Preanalytics/Notes:

Blood sampling in an upright sitting posture after 20-30 minutes of rest. Centrifuge EDTA blood immediately after sampling and transfer supernatant plasma into a new tube, label this tube accordingly, freeze and dispatch deep-frozen. Patients should stop taking medications that affect the SNS a few days before blood sampling, if possible. Avoid tropical fruits, nuts, coffee, cocoa, tea before blood sampling.

Follow up studies of tumor markers should always be done with the same testkit.

Method: Liquid chromatography-tandem mass spectr
Set-up: Mon Tue Wed Thu Fri Sat Sun
Duration: 6 days
Indication/Significance:
  • Suspected catecholamine excess

  • Hypertonia of unclear origin with paroxysmal episodes (hypertensive crises)

  • Hypertonia at a young age (< 30 years)

  • Therapy-resistant hypertonia (3 and more medications)

  • Paradoxical increase during treatment with beta blockers

  • Manifestation of a hypertonia during treatment with tricyclic antidepressants

  • Incidentaloma

  • Anamnestic references to family history: Phaeochromocytoma, paraganglioma, von Hippel-Lindau syndrome, medullary thyroid carcinoma, multiple endocrine neoplasia type II

The determination of free metanephrines in plasma is currently the most sensitive screening method for catecholamine excess!

Interpretation:

initial letter


Abrechnung GOÄ

Die Kosten werden für den i. d. R. genutzten 1,15-fachen GOÄ-Satz dargestellt. Wird die Unter­suchung nicht in Ihrem regionalen Labor durch­geführt, erfolgt die Analyse in dem Labor, das im Leistungs­ver­zeich­nis genannt ist. In diesem Fall gilt der dort für die Untersuchung angegebene Preis.