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Cortisol (Serum (s))
| Specimens: | 500 µl Serum (s) |
| Preanalytics/Notes: | Avoid stress situations during sampling. Take into account the pronounced circadian rhythm: maximum in the morning and minimum at midnight; the administration of oestrogen and pregnancy lead to increased total cortisol due to the change in transcortin and protein deficiency lead to a decreased total cortisol with physiologically free cortisol (biologically active). Patients receiving high doses of biotin (> 5 mg / day) should be sampled at least 8 hours after the last application, as high levels of biotin may interfere with the test system. |
| Method: | ECLIA |
| Dimension: | µg/dl |
| Alternate dimension: | nmol/l (Factor: 27.59) Calculator |
| Set-up: | Mon Tue Wed Thu Fri Sat Sun |
| Duration: | 1 day |
| Indication/Significance: |
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| Interpretation: |
Increased in the case more… Increased in the case of: Cushing's syndrome, stress reaction, adiposity, alcoholism, endogenous depression, anorexia nervosa Decreased in the case of: Primary or secondary hypoadrenalism (Addison's disease) If an adrenocortical insufficiency is substituted with hydrocortisone (cortisol), the clinical data is decisive for therapy monitoring. |
| Further tests: | Cortisol in the urine; ACTH short test, dexamethasone suppression test |
Reference range / valuation (openclose)
| male | ||
|---|---|---|
| from 0 - 14 Years | 2,1 - 20,5 µg/dl | |
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Adults: Morning (7 - 9.00 hrs.): 4.8 - 19.5 µg/dl [133 - 537 nmol/l] Afternoon (15 - 17.00 hrs.): 2.5 - 11.9 µg/dl [68 - 327 nmol/l] Night (sleeping) (24.00 hrs.): < 1.8 µg/dl [< 50 nmol/l] Children and Adolescents (in the morning): < 15 years: 2.1 - 20.5 µg/dl [58 - 568 nmol/l] 15 - 20 years (female): 1.7 - 13.2 µg/dl [47 - 367 nmol/l] 15 - 20 years (male): 3.7 - 29.3 µg/dl [103 - 814 nmol/l] after 1 mg Dexamethasone: < 1.8 µg/dl [< 50 nmol/l] after ACTH: > 20 µg/dl [> 552 nmol/l] A basal cortisol value above the stated reference range indicates Cushings syndrome. Further differential diagnosis on the basis of the cortisol concentration alone is not possible. A cortisol value within the reference range does not necessarily rule out Cushings syndrome. Increased secretion can occur, however, when the typical circadian rhythm, with drop in cortisol concentration between 8 - 24 hrs, is not followed. Therefore, to verify the diagnosis, we suggest the performance of other analyses (e.g. cortisol at 24.00 hrs (e.g. from saliva), cortisol in 24hr urine and Dexamethasone test). High cortisol levels, partly due to not adhering to the circadian rhythm, can also be seen, however, in stressful conditions (severe illness, operations), acute psychosis, adiposis, anorexia nervosa, alcoholism and high oestrogen concentration (e.g. in pregnancy, oestrogen therapy and oral contraceptives). |
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| from 15 Years - 19 Years | 3,7 - 29,3 µg/dl | |
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Adults: Morning (7 - 9.00 hrs.): 4.8 - 19.5 µg/dl [133 - 537 nmol/l] Afternoon (15 - 17.00 hrs.): 2.5 - 11.9 µg/dl [68 - 327 nmol/l] Night (sleeping) (24.00 hrs.): < 1.8 µg/dl [< 50 nmol/l] Children and Adolescents (in the morning): < 15 years: 2.1 - 20.5 µg/dl [58 - 568 nmol/l] 15 - 20 years (female): 1.7 - 13.2 µg/dl [47 - 367 nmol/l] 15 - 20 years (male): 3.7 - 29.3 µg/dl [103 - 814 nmol/l] after 1 mg Dexamethasone: < 1.8 µg/dl [< 50 nmol/l] after ACTH: > 20 µg/dl [> 552 nmol/l] A basal cortisol value above the stated reference range indicates Cushings syndrome. Further differential diagnosis on the basis of the cortisol concentration alone is not possible. A cortisol value within the reference range does not necessarily rule out Cushings syndrome. Increased secretion can occur, however, when the typical circadian rhythm, with drop in cortisol concentration between 8 - 24 hrs, is not followed. Therefore, to verify the diagnosis, we suggest the performance of other analyses (e.g. cortisol at 24.00 hrs (e.g. from saliva), cortisol in 24hr urine and Dexamethasone test). High cortisol levels, partly due to not adhering to the circadian rhythm, can also be seen, however, in stressful conditions (severe illness, operations), acute psychosis, adiposis, anorexia nervosa, alcoholism and high oestrogen concentration (e.g. in pregnancy, oestrogen therapy and oral contraceptives). |
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| from 20 Years - 120 Years | 4,8 - 19,5 µg/dl | |
|
Adults: Morning (7 - 9.00 hrs.): 4.8 - 19.5 µg/dl [133 - 537 nmol/l] Afternoon (15 - 17.00 hrs.): 2.5 - 11.9 µg/dl [68 - 327 nmol/l] Night (sleeping) (24.00 hrs.): < 1.8 µg/dl [< 50 nmol/l] Children and Adolescents (in the morning): < 15 years: 2.1 - 20.5 µg/dl [58 - 568 nmol/l] 15 - 20 years (female): 1.7 - 13.2 µg/dl [47 - 367 nmol/l] 15 - 20 years (male): 3.7 - 29.3 µg/dl [103 - 814 nmol/l] after 1 mg Dexamethasone: < 1.8 µg/dl [< 50 nmol/l] after ACTH: > 20 µg/dl [> 552 nmol/l] A basal cortisol value above the stated reference range indicates Cushings syndrome. Further differential diagnosis on the basis of the cortisol concentration alone is not possible. A cortisol value within the reference range does not necessarily rule out Cushings syndrome. Increased secretion can occur, however, when the typical circadian rhythm, with drop in cortisol concentration between 8 - 24 hrs, is not followed. Therefore, to verify the diagnosis, we suggest the performance of other analyses (e.g. cortisol at 24.00 hrs (e.g. from saliva), cortisol in 24hr urine and Dexamethasone test). High cortisol levels, partly due to not adhering to the circadian rhythm, can also be seen, however, in stressful conditions (severe illness, operations), acute psychosis, adiposis, anorexia nervosa, alcoholism and high oestrogen concentration (e.g. in pregnancy, oestrogen therapy and oral contraceptives). |
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| female | ||
|---|---|---|
| from 0 - 14 Years | 2,1 - 20,5 µg/dl | |
|
Adults: Morning (7 - 9.00 hrs.): 4.8 - 19.5 µg/dl [133 - 537 nmol/l] Afternoon (15 - 17.00 hrs.): 2.5 - 11.9 µg/dl [68 - 327 nmol/l] Night (sleeping) (24.00 hrs.): < 1.8 µg/dl [< 50 nmol/l] Children and Adolescents (in the morning): < 15 years: 2.1 - 20.5 µg/dl [58 - 568 nmol/l] 15 - 20 years (female): 1.7 - 13.2 µg/dl [47 - 367 nmol/l] 15 - 20 years (male): 3.7 - 29.3 µg/dl [103 - 814 nmol/l] after 1 mg Dexamethasone: < 1.8 µg/dl [< 50 nmol/l] after ACTH: > 20 µg/dl [> 552 nmol/l] A basal cortisol value above the stated reference range indicates Cushings syndrome. Further differential diagnosis on the basis of the cortisol concentration alone is not possible. A cortisol value within the reference range does not necessarily rule out Cushings syndrome. Increased secretion can occur, however, when the typical circadian rhythm, with drop in cortisol concentration between 8 - 24 hrs, is not followed. Therefore, to verify the diagnosis, we suggest the performance of other analyses (e.g. cortisol at 24.00 hrs (e.g. from saliva), cortisol in 24hr urine and Dexamethasone test). High cortisol levels, partly due to not adhering to the circadian rhythm, can also be seen, however, in stressful conditions (severe illness, operations), acute psychosis, adiposis, anorexia nervosa, alcoholism and high oestrogen concentration (e.g. in pregnancy, oestrogen therapy and oral contraceptives). |
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| from 15 Years - 19 Years | 1,7 - 13,2 µg/dl | |
|
Adults: Morning (7 - 9.00 hrs.): 4.8 - 19.5 µg/dl [133 - 537 nmol/l] Afternoon (15 - 17.00 hrs.): 2.5 - 11.9 µg/dl [68 - 327 nmol/l] Night (sleeping) (24.00 hrs.): < 1.8 µg/dl [< 50 nmol/l] Children and Adolescents (in the morning): < 15 years: 2.1 - 20.5 µg/dl [58 - 568 nmol/l] 15 - 20 years (female): 1.7 - 13.2 µg/dl [47 - 367 nmol/l] 15 - 20 years (male): 3.7 - 29.3 µg/dl [103 - 814 nmol/l] after 1 mg Dexamethasone: < 1.8 µg/dl [< 50 nmol/l] after ACTH: > 20 µg/dl [> 552 nmol/l] A basal cortisol value above the stated reference range indicates Cushings syndrome. Further differential diagnosis on the basis of the cortisol concentration alone is not possible. A cortisol value within the reference range does not necessarily rule out Cushings syndrome. Increased secretion can occur, however, when the typical circadian rhythm, with drop in cortisol concentration between 8 - 24 hrs, is not followed. Therefore, to verify the diagnosis, we suggest the performance of other analyses (e.g. cortisol at 24.00 hrs (e.g. from saliva), cortisol in 24hr urine and Dexamethasone test). High cortisol levels, partly due to not adhering to the circadian rhythm, can also be seen, however, in stressful conditions (severe illness, operations), acute psychosis, adiposis, anorexia nervosa, alcoholism and high oestrogen concentration (e.g. in pregnancy, oestrogen therapy and oral contraceptives). |
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| from 20 Years - 120 Years | 4,8 - 19,5 µg/dl | |
|
Adults: Morning (7 - 9.00 hrs.): 4.8 - 19.5 µg/dl [133 - 537 nmol/l] Afternoon (15 - 17.00 hrs.): 2.5 - 11.9 µg/dl [68 - 327 nmol/l] Night (sleeping) (24.00 hrs.): < 1.8 µg/dl [< 50 nmol/l] Children and Adolescents (in the morning): < 15 years: 2.1 - 20.5 µg/dl [58 - 568 nmol/l] 15 - 20 years (female): 1.7 - 13.2 µg/dl [47 - 367 nmol/l] 15 - 20 years (male): 3.7 - 29.3 µg/dl [103 - 814 nmol/l] after 1 mg Dexamethasone: < 1.8 µg/dl [< 50 nmol/l] after ACTH: > 20 µg/dl [> 552 nmol/l] A basal cortisol value above the stated reference range indicates Cushings syndrome. Further differential diagnosis on the basis of the cortisol concentration alone is not possible. A cortisol value within the reference range does not necessarily rule out Cushings syndrome. Increased secretion can occur, however, when the typical circadian rhythm, with drop in cortisol concentration between 8 - 24 hrs, is not followed. Therefore, to verify the diagnosis, we suggest the performance of other analyses (e.g. cortisol at 24.00 hrs (e.g. from saliva), cortisol in 24hr urine and Dexamethasone test). High cortisol levels, partly due to not adhering to the circadian rhythm, can also be seen, however, in stressful conditions (severe illness, operations), acute psychosis, adiposis, anorexia nervosa, alcoholism and high oestrogen concentration (e.g. in pregnancy, oestrogen therapy and oral contraceptives). |
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Representation of age: "from" refers to the commenced year(s) (month) of age; "until" refers to the completed year(s) (month) of age.
initial letter
Abrechnung GOÄ
Die Kosten werden für den i. d. R. genutzten 1,15-fachen GOÄ-Satz dargestellt. Wird die Untersuchung nicht in Ihrem regionalen Labor durchgeführt, erfolgt die Analyse in dem Labor, das im Leistungsverzeichnis genannt ist. In diesem Fall gilt der dort für die Untersuchung angegebene Preis.