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Ciclosporin A (LC-MS/MS) (eb) (EDTA blood (eb))
| Testcode: | E_CICLOS |
| Specimens: | 150 µl EDTA blood (eb) |
| Method: | Liquid chromatography-tandem mass spectr |
| Dimension: | µg/l |
| Set-up: | Mon Tue Wed Thu Fri Sat Sun |
| Duration: | 2 days |
| Indication/Significance: | Therapeutic drug monitoring, adverse effects of drugs, unsatisfactory therapeutic effect
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| Interpretation: |
With levels > 400 more… With levels > 400 µg/l, toxicity is highly likely. |
Reference range / valuation (openclose)
| both sex | ||
|---|---|---|
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Therapeutic ranges for ciclosporin A (trough concentration, LC-MS/MS): Kidney transplantation initial therapy 150-225 µg/l maintenance therapy 100-150 µg/l Liver transplantation initial therapy 225-300 µg/l maintenance therapy 100-150 µg/l Heart/lung transplantation initial therapy 250-350 µg/l maintenance therapy 150-250 µg/l Stem cell transplantation initial therapy 200-300 µg/l* maintenance therapy 150-200 µg/l** Lower therapeutic ranges are targeted in therapy protocols with ciclosporin A dose minimization. * GvHD prophylaxis ** GvHD treatment (with corticosteroids) |
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Abrechnung GOÄ
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