C1-esterase inhibitor (protein) (Citrated plasma (cp))
| Testcode: | E_C1ESTP |
| Specimens: | 1 ml Citrated plasma (cp) |
| Preanalytics/Notes: | Withdraw 5 ml of citrated blood, immediately centrifuge blood after sampling, transfer supernatant citrated plasma into a new tube and label accordingly. Note: Citrate plasma is suitable for both analyses (determination of activity and protein). If both of these tests are required, please send in frozen citrate plasma. |
| Method: | Nephelometry |
| Dimension: | g/l |
| Set-up: | Mon Tue Wed Thu Fri Sat Sun |
| Duration: | 3 days |
| Indication/Significance: |
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| Interpretation: |
Increased in the case of more… Increased in the case of acute phase reactions. Decreased with hereditary angioedema. C1 esterase inhibitor (C1-INH) is the only inhibitor of complement C1r and C1s and thus the most important regulator of the classical pathway of complement activation. A disturbance of the inhibition leads to the so-called angioedema (Quincke's oedema, glottic oedema). In the case of the congenital form, there can be a deficiency (low C1 INH concentration and activity) or a functional loss (only C1 INH activity reduced). An acquired deficiency (e.g. with B-cell lymphomas) is described as well. With a clinically manifest disease, the activities are usually < 25 % of the standard value. The complement factors C2 and C4 are considerably reduced owing to increased consumption, whereas C3 is normal. C1 INH is increased with acute inflammations. |
| Further tests: | C3 and C4 complement |
Reference range / valuation (openclose)
| both sex | ||
|---|---|---|
| 0,18 - 0,32 g/l | ||
initial letter
Abrechnung GOÄ
Die Kosten werden für den i. d. R. genutzten 1,15-fachen GOÄ-Satz dargestellt. Wird die Untersuchung nicht in Ihrem regionalen Labor durchgeführt, erfolgt die Analyse in dem Labor, das im Leistungsverzeichnis genannt ist. In diesem Fall gilt der dort für die Untersuchung angegebene Preis.