C1-esterase inhibitor (activity) (Citrated plasma, frozen (cp))
| Specimens: | 1 ml Citrated plasma, frozen (cp) |
| Preanalytics/Notes: | To avoid clotting, please mix test tube carefully several times directly after collection of blood. Centrifugation process should be started immediately. Please centrifuge sample at least for 15 minutes at 1500 x g. Plasma / supernatant should be transferred by pipette to a collection tube without any buffer or other substances. Please label as citrated plasma. Freeze and send frozen. No blood sampling from central venous catheter. If additional coagulation tests are ordered (e.g. factor II - XIII), at least one extra tube of frozen citrated plasma is needed. |
| Method: | Chromogenic assay |
| Dimension: | % |
| Set-up: | Mon Tue Wed Thu Fri Sat Sun |
| Duration: | 3 days |
| Indication/Significance: |
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| Interpretation: |
Increased in the case of more… Increased in the case of acute phase reactions. Decreased with hereditary angioedema. C1 esterase inhibitor (C1-INH) is the only inhibitor of complement C1r and C1s and thus the most important regulator of the classical pathway of complement activation. A disturbance of the inhibition leads to the so-called angioedema (Quincke's oedema, glottic oedema). In the case of the congenital form, there can be a deficiency (low C1 INH concentration and activity) or a functional loss (only C1 INH activity reduced). An acquired deficiency (e.g. with B-cell lymphomas) is described as well. With a clinically manifest disease, the activities are usually < 25 % of the standard value. The complement factors C2 and C4 are considerably reduced owing to increased consumption, whereas C3 is normal. C1 INH is increased with acute inflammations. |
| Further tests: | C3 and C4 complement |
Reference range / valuation (openclose)
| both sex | ||
|---|---|---|
| from 0 - 2 Months | ||
|
Adult reference ranges (70 - 130%) are reached within the first three months of life. |
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| from 3 Months - 120 Years | 70 - 130 % | |
Representation of age: "from" refers to the commenced year(s) (month) of age; "until" refers to the completed year(s) (month) of age.
initial letter
Abrechnung GOÄ
Die Kosten werden für den i. d. R. genutzten 1,15-fachen GOÄ-Satz dargestellt. Wird die Untersuchung nicht in Ihrem regionalen Labor durchgeführt, erfolgt die Analyse in dem Labor, das im Leistungsverzeichnis genannt ist. In diesem Fall gilt der dort für die Untersuchung angegebene Preis.