C-peptide (Serum (s), frozen)
| Testcode: | E_CPEPR |
| Specimens: | 500 µl Serum (s), frozen |
| Preanalytics/Notes: | Let whole blood coagulate after sampling, centrifuge, transfer supernatant serum into a new tube, label the tube accordingly, freeze and dispatch deep-frozen. Patients receiving high doses of biotin (> 5 mg / day) should be sampled at least 8 hours after the last application, as high levels of biotin may interfere with the test system. |
| Method: | ECLIA |
| Dimension: | ng/ml |
| Alternate dimension: | nmol/l (Factor: 0.333) Calculator |
| Set-up: | Mon Tue Wed Thu Fri Sat Sun |
| Duration: | 1 day |
| Indication/Significance: |
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| Interpretation: |
Increased: Indication of more… Increased: Indication of endogenous production, e.g. in the case of an insulinoma, also in the case of exogenously-induced hypoglycaemia caused by sulphonylurea, postprandial
Decreased: Exogenously administered insulin, type I diabetesC peptide develops in equimolar amounts like insulin by splitting from proinsulin and reflects the endogenous insulin secretion. Owing to its longer half-life (30 - 40 minutes) and the lower metabolisation, it is a better marker of the B cell function than insulin. It serves the estimation of the residual insulin secretion and is important in the DD of hypoglycaemia in the case of a suspected insulinoma to differentiate from an exogenous insulin supply. In most cases the determination within the scope of function tests (e.g. glucose tolerance test, hunger test, glucagon test) with a simultaneous determination of glucose and, if required insulin, is more reliable. |
| Further tests: | see diagnosis of diabetes mellitus |
Reference range / valuation (openclose)
| both sex | ||
|---|---|---|
| 1,1 - 4,4 ng/ml | ||
|
After 12 hours fasting. The reference range quoted applies only to baseline or fasting samples and not for specimens obtained after stimulation. |
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initial letter
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