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Antibody screen (LISS/Coombs) (EDTA blood (eb))

Specimens:	7 ml EDTA blood (eb)
Preanalytics/Notes:	Every sample container must be clearly labelled (last name, first name, date of birth or alternatively patient ID/bar code). The examination request must be filled out completely and signed by the physician withdrawing the sample. It is necessary to clearly assign the required test to the corresponding sample container.
Method:	Agglutination test
Set-up:	Mon Tue Wed Thu Fri Sat Sun
Duration:	1 day
Indication/Significance:	Part of very blood grouping test Transfusions: The antibody screening is performed before every transfusion event and has to be repeated in cross-match test, if the blood sample with which the last antibody screening was carried out was drawn more than 3 days before. Exception: resultd valid for 7 days if there was no transfusion or pregnancy in the previous 3 months Pregnancy: The test is performed to identify irregular maternal antibodies against RBC antigens which can possibly penetrate the placenta and cause fetal hemolysis Within the scope of the prematernity medical care in Germany, the antibody screening has to be performed twice during pregnancy: 4th to 8th and 24th to 27th week of pregnancy. A third test is recommended for Rh-negative mothers in the second trimenon.
Interpretation:	If anti-erythrocyte more… If anti-erythrocyte antibodies are detected, assessment with regard to the clinical relevance is necessary. Anti-D prophylaxis for Rh-negative mothers: An irregular anti-D is detected which possibly cannot be detected weeks later. When sending samples for the antibody screening post partum, the laboratory should always be informed of any anti-D prophylaxis that has been carried out. close
Further tests:	If the result of the antibody screening is positive, additional antibody differentiations is necessary in many cases.

Reference range / valuation (openclose)

both sex
	negative

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Abrechnung GOÄ

Die Kosten werden für den i. d. R. genutzten 1,15-fachen GOÄ-Satz dargestellt. Wird die Untersuchung nicht in Ihrem regionalen Labor durchgeführt, erfolgt die Analyse in dem Labor, das im Leistungsverzeichnis genannt ist. In diesem Fall gilt der dort für die Untersuchung angegebene Preis.