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17-Hydroxyprogesterone (Serum (s))

Testcode:	E_OHPO
Specimens:	700 µl Serum (s)
Preanalytics/Notes:	17-Hydroxyprogesterone shows a circadian rhythm, therefore blood sampling should take place in the morning between 8.00 and 10.00am, in women during the early follicular maturation phase, i.e. on the 1st to 6th day after menstruation.
Method:	Liquid chromatography-tandem mass spectr
Dimension:	ng/ml
Alternate dimension:	nmol/l (Factor: 3.03) Calculator
Set-up:	Mon Tue Wed Thu Fri Sat Sun
Duration:	2 days
Indication/Significance:	Suspected 21-hydroxylase deficiency, the most common form of congenital adrenal hyperplasia (CAH) Pubertas precox Virilisation Hirsutism Androgen-producing tumours
Interpretation:	Increased: Congenital more… Increased: Congenital adrenal hyperplasia (CAH). CAH belongs to a group of autosomal recessive diseases which occur as a consequence of the deficiency of one of the five enzymes involved in the biosynthesis of cortisol. In 90 % of the cases, there is a 21-hydroxylase deficiency, also referred to as CYP21, CYP21A2 or P450c21. 17-Hydroxyprogesterone is converted to 11-desoxycortisol, a cortisol precursor. close

Reference range / valuation (openclose)

male
0 Years	< 0,80 ng/ml
Reference interval derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409
from 1 Year - 4 Years	< 0,85 ng/ml
Reference interval derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409
from 5 Years - 7 Years	< 0,69 ng/ml
Reference interval derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409
from 8 Years - 9 Years	< 0,69 ng/ml
Reference interval according to Tanner stage derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409. Males Tanner stage I <= 0.59 ng/ml Tanner stage II <= 0.73 ng/ml Tanner stage III <= 1.19 ng/ml Tanner stage IV 0.26 - 1.69 ng/ml Tanner stage V 0.39 - 2.18 ng/ml Females Tanner stage I <= 0.53 ng/ml Tanner stage II <= 0.76 ng/ml Tanner stage III <= 1.32 ng/ml Tanner stage IV 0.16 - 1.98 ng/ml Tanner stage V 0.13 - 2.45 ng/ml
from 10 Years - 14 Years	< 1,28 ng/ml
Reference interval according to Tanner stage derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409. Males Tanner stage I <= 0.59 ng/ml Tanner stage II <= 0.73 ng/ml Tanner stage III <= 1.19 ng/ml Tanner stage IV 0.26 - 1.69 ng/ml Tanner stage V 0.39 - 2.18 ng/ml Females Tanner stage I <= 0.53 ng/ml Tanner stage II <= 0.76 ng/ml Tanner stage III <= 1.32 ng/ml Tanner stage IV 0.16 - 1.98 ng/ml Tanner stage V 0.13 - 2.45 ng/ml
from 15 Years - 17 Years	0,41 - 2,26 ng/ml
Reference interval according to Tanner stage derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409. Males Tanner stage I <= 0.59 ng/ml Tanner stage II <= 0.73 ng/ml Tanner stage III <= 1.19 ng/ml Tanner stage IV 0.26 - 1.69 ng/ml Tanner stage V 0.39 - 2.18 ng/ml Females Tanner stage I <= 0.53 ng/ml Tanner stage II <= 0.76 ng/ml Tanner stage III <= 1.32 ng/ml Tanner stage IV 0.16 - 1.98 ng/ml Tanner stage V 0.13 - 2.45 ng/ml
from 18 Years - 49 Years	0,48 - 1,76 ng/ml
from 50 Years - 120 Years	0,44 - 1,79 ng/ml

female
0 Years	< 0,76 ng/ml
Reference interval derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409
from 1 Year - 4 Years	< 0,64 ng/ml
Reference interval derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409
from 5 Years - 7 Years	< 0,59 ng/ml
Reference interval derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409
from 8 Years - 9 Years	< 0,59 ng/ml
Reference interval according to Tanner stage derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409. Males Tanner stage I <= 0.59 ng/ml Tanner stage II <= 0.73 ng/ml Tanner stage III <= 1.19 ng/ml Tanner stage IV 0.26 - 1.69 ng/ml Tanner stage V 0.39 - 2.18 ng/ml Females Tanner stage I <= 0.53 ng/ml Tanner stage II <= 0.76 ng/ml Tanner stage III <= 1.32 ng/ml Tanner stage IV 0.16 - 1.98 ng/ml Tanner stage V 0.13 - 2.45 ng/ml
from 10 Years - 14 Years	< 2,36 ng/ml
Reference interval according to Tanner stage derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409. Males Tanner stage I <= 0.59 ng/ml Tanner stage II <= 0.73 ng/ml Tanner stage III <= 1.19 ng/ml Tanner stage IV 0.26 - 1.69 ng/ml Tanner stage V 0.39 - 2.18 ng/ml Females Tanner stage I <= 0.53 ng/ml Tanner stage II <= 0.76 ng/ml Tanner stage III <= 1.32 ng/ml Tanner stage IV 0.16 - 1.98 ng/ml Tanner stage V 0.13 - 2.45 ng/ml
from 15 Years - 17 Years	< 2,10 ng/ml
Reference interval according to Tanner stage derived from Bae et al. J Ster Biochem & Mol Biol 193 (2019), 105409. Males Tanner stage I <= 0.59 ng/ml Tanner stage II <= 0.73 ng/ml Tanner stage III <= 1.19 ng/ml Tanner stage IV 0.26 - 1.69 ng/ml Tanner stage V 0.39 - 2.18 ng/ml Females Tanner stage I <= 0.53 ng/ml Tanner stage II <= 0.76 ng/ml Tanner stage III <= 1.32 ng/ml Tanner stage IV 0.16 - 1.98 ng/ml Tanner stage V 0.13 - 2.45 ng/ml
from 18 Years - 19 Years	< 2,10 ng/ml
from 20 Years - 120 Years
Reference interval for women: Postmenopausal 0.05 - 0.58 ng/ml Follicular Phase 0.13 - 0.80 ng/ml Ovulation phase 0.16 - 2.17 ng/ml Luteal Phase 0.17 - 2.91 ng/ml Oral contraceptives* 0.04 - 0.66 ng/ml Higher concentrations are observed during pregnancy. *Reference range derived from Eisenhofer G et al. Clin Chim Acta 470 (2017), 115.

Representation of age: "from" refers to the commenced year(s) (month) of age; "until" refers to the completed year(s) (month) of age.

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Abrechnung GOÄ

Die Kosten werden für den i. d. R. genutzten 1,15-fachen GOÄ-Satz dargestellt. Wird die Untersuchung nicht in Ihrem regionalen Labor durchgeführt, erfolgt die Analyse in dem Labor, das im Leistungsverzeichnis genannt ist. In diesem Fall gilt der dort für die Untersuchung angegebene Preis.