17-Hydroxyprogesterone (Serum (s))

Specimens:	500 µl Serum (s)
Preanalytics/Notes:	17-Hydroxyprogesterone shows a circadian rhythm, therefore blood sampling should take place in the morning between 8.00 and 10.00am, in women during the early follicular maturation phase, i.e. on the 1st to 6th day after menstruation.
Method:	RIA
Dimension:	ng/ml
Alternate dimension:	nmol/l (Factor: 3.03) Calculator
Set-up:	Mon Tue Wed Thu Fri Sat Sun
Duration:	2 days
Indication/Significance:	Suspected 21-hydroxylase deficiency, the most common form of congenital adrenal hyperplasia (CAH) Pubertas precox Virilisation Hirsutism Androgen-producing tumours
Interpretation:	Increased: Congenital more… Increased: Congenital adrenal hyperplasia (CAH). CAH belongs to a group of autosomal recessive diseases which occur as a consequence of the deficiency of one of the five enzymes involved in the biosynthesis of cortisol. In 90 % of the cases, there is a 21-hydroxylase deficiency, also referred to as CYP21, CYP21A2 or P450c21. 17-Hydroxyprogesterone is converted to 11-desoxycortisol, a cortisol precursor. close

male
from 0 - 2 Months
Children under 3 months of age should not be measured without extraction due to an increased concentration of 17 alpha-OH-pregnenolone despite very low cross-reactivity of the used antibody.
from 3 Months - 5 Months	0,10 - 7,90 ng/ml
from 6 Months - 11 Months	0,10 - 2,00 ng/ml
from 12 Months - 4 Years	0,25 - 0,60 ng/ml
from 5 Years - 7 Years	0,33 - 1,20 ng/ml
from 8 Years - 16 Years	0,55 - 1,60 ng/ml
Tanner stage II and III 0.64 ng/ml - 1.7 ng/ml Women: Tanner IV and V 0.67 ng/ml - 2.0 ng/ml Men: Tanner IV and V 1.2 ng/ml - 3.4 ng/ml
from 17 Years - 120 Years	0,67 - 3,32 ng/ml

female
from 0 - 2 Months
Children under 3 months of age should not be measured without extraction due to an increased concentration of 17 alpha-OH-pregnenolone despite very low cross-reactivity of the used antibody.
from 3 Months - 5 Months	0,10 - 5,20 ng/ml
from 6 Months - 11 Months	0,10 - 0,95 ng/ml
from 12 Months - 4 Years	0,25 - 0,60 ng/ml
from 5 Years - 7 Years	0,33 - 1,20 ng/ml
from 8 Years - 16 Years	0,55 - 1,60 ng/ml
Tanner stage II and III 0.64 ng/ml - 1.7 ng/ml Women: Tanner IV and V 0.67 ng/ml - 2.0 ng/ml Men: Tanner IV and V 1.2 ng/ml - 3.4 ng/ml
from 17 Years - 120 Years
Follicular phase: 0.41 - 2.27 ng/ml [1.24 - 6.88 nmol/l] Luteal phase: 0.23 - 3.87 ng/ml [0.70 - 11.73 nmol/l] Pregnancy: 1st Trimester: 2.60 - 7.95 ng/ml [7.88 - 24.09 nmol/l] 2nd Trimester: 1.83 - 9.74 ng/ml [5.55 - 29.51 nmol/l] 3rd Trimester: 3.54 - 18.97 ng/ml [10.73 - 57.48 nmol/l]

Representation of age: "from" refers to the commenced year(s) (month) of age; "until" refers to the completed year(s) (month) of age.