PKU screen (Other)

Specimens:	Other
Preanalytics/Notes:	Saturate the filter paper test card with 4 drops of blood and cover the entire field; recommended sampling time: 3 - 5 days after birth specimen: blood card
Method:	Tandem mass-spectrometry
Set-up:	Mon Tue Wed Thu Fri Sat Sun
Duration:	5 days
Indication/Significance:	Early detection of a metabolic disorder of phenylalanine
Interpretation:	Increased in the case more… Increased in the case of: Phenylketonuria Benign persistent hyperphenylalaninaemia Caution: False-negative test results are possible in the following cases: Performance of the screening test much earlier than on the 5th day of life (thus only low phenylalanine intake up to the test) Within 4 days of a blood transfusion Insufficient impregnation of the filter paper card Vomiting in the first days of life (insufficient phenylalanine intake) Nutrition with pure glucose-electrolyte solution close

non-accredited test