Free light chains, type lambda (urine) (Urine (u))
| Specimens: | 10 ml Urine (u) |
| Preanalytics/Notes: | Spot morning urine or 10 ml of a thoroughly mixed 24 h urine collection without additive are suitable. |
| Method: | Nephelometry |
| Dimension: | mg/l |
| Set-up: | Mon Tue Wed Thu Fri Sat Sun |
| Duration: | 4 days |
| Indication/Significance: |
Determination of free light chains in the serum is to be preferred to the determination of FLCs in urine, as free light chains are always detectable in serum first; Bence Jones proteinuria is a typical overflow proteinuria meaning that only when the threshold of tubular reabsorption has been exceeded, are the glomerular filtrated FLCs detectable in urine. If the free light chains in urine are requested, it is advisable to always carry out a determination in serum in parallel for the purpose of a comprehensive assessment. |
| Interpretation: |
The determination of more… The determination of free light chains in the serum is characterised by a higher diagnostic sensitivity compared to immunofixation electrophoresis. The free light chains should always be determined for both types (Kappa, Lambda) and subsequently the ratio formation. This combined evaluation then allows for a quite reliable diagnosis and assessment of the progress. |
| Further tests: | Those tests shall be performed in serum NOT urine: immunofixation, quantitative immunoglobuline, free light chains (kappa, lambda), quantitätive and/or monoclonal IgA-,IgG- and IgM-HLC with corresponding ratio to evaluate the clonality. |
performance by Bioscientia medical service centers
Reference range / valuation (openclose)
| both sex | ||
|---|---|---|
| < 3,79 mg/l | ||
initial letter
Abrechnung GOÄ
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